The following two cases represent the first reports of apparently successful treatment of primary periodic paralysis (PPP) with CoQ10.1
A 29-year-old man is treated at a hospital in China. The patient described attacks of recurrent limb weakness starting from age 19. The attacks ranged in severity from mild to complete paralysis of all four extremities. The frequency of attacks had recently increased over the last six months, from once a month to once a week.
Apparent triggers included poor sleep and exposure to cold. Potassium levels during attacks were normal, and potassium supplementation had no effect.
Routine blood and biochemical tests were normal. Genetic testing revealed a mutation in the SCN4A gene indicative of PPP.
Prophylactic medicine was unavailable in the treating hospital, so the patient was treated with CoQ10 10 mg three times daily. Over the subsequent three months of treatment, the patient remained asymptomatic despite exposure to known triggers.
A 50-year-old man described a history of sudden attacks of generalized muscle weakness with myalgia and stiffness, starting at age 37. The attacks had recently increased in frequency from once or twice per month to almost twice a week.
His father and two siblings had experienced similar, though less severe attacks. Potassium levels during attacks ranged as low as 2.8 mmol/L. Symptoms were alleviated with potassium administration. Thyroid function tests were normal. Long exercise test was positive. Genetic testing for CACNA1S and SCN4A mutations were negative.
The man was given a trial of 30 mg three times daily idebenone (a synthetic quinone similar to CoQ10). During the subsequent one month of treatment, he remained asymptomatic.
1. Da Y, Lei L, Jurkat-Rott K, et al. Successful treatment of periodic paralysis with coenzyme Q10: two case reports. Acta Myol. 2016;35:107-108.