Risk factors for MS; aspirin and exercise endurance; and IV immunoglobulin in young patients with ocular complications of MS. Here are brief synopses of 3 more presentations from the 7th Joint ECTRIMS-ACTRIMS conference. (Read the first 3 summaries here.)
I. ASPIRIN IMPROVES EXERCISE ENDURANCE
Aspirin may represent an easy, economical treatment to enable MS patients to gain the benefits of exercise.
A double-blind, randomized, placebo-controlled, crossover trial studied whether aspirin can improve exercise performance and attenuate exercise-related body temperature increase in 12 MS patients. Eight of the 12 patients reported overheating during exercise. All patients completed 2 maximal aerobic exercise sessions and received either a standard dose of 650 mg aspirin or placebo. After 1 hour, participants performed a progressive ramped exercise test with a lower-body cycle ergometer.
Exercise performance improved after pre-treatment with aspirin as compared to placebo, and the effect of aspirin was larger among the heat-sensitive patients. Exercise-induced body temperature increase did not differ between the treatment group and controls. However, the heat-sensitive subgroup had a 56% attenuation of body temperature increase after exercise with aspirin.
Cooling treatments, such as cold bath pre-cooling and vacuum hand-cooling chambers, have been proven to be effective in MS patients. The antipyretic effects of aspirin make it a convenient, inexpensive, readily accessible, and unobtrusive method of body cooling for MS patients, allowing them to exercise to their full capacity.
Aspirin improves exercise endurance in multiple sclerosis: Pilot findings from a double-blind randomized placebo-controlled crossover trial
ECTRIMS Online Library. Leavitt V. Oct 26, 2017; 200459
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