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Published in the journal Neurology,1 a longitudinal study evaluating the dual role of subjective cognitive decline and the presence of beta amyloid burden in 136 healthy elderly patients followed for 4 years.
Turns out that beta amyloid burden combined with subjective cognitive decline, identified patients at greatest risk of memory loss and global loss of cognitive function.
Amyloid burden alone was not indicative of these risks.
1. Vogel JW, Varga Doležalová M, La Joie R, et al. Subjective cognitive decline and β-amyloid burden predict cognitive change in healthy elderly. Neurology. 2017 Oct [ahead of print].