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Psychosis in Parkinson Disease

Psychosis in Parkinson Disease

  • For some patients with PD, the neuropsychiatric complications are great.
  • A host of neuropsychiatric disorders are intrinsic to Parkinson disease or occur as a complication of the dopaminergic therapies (dopamine agonists, levodopa) or anticholinergic medications used to treat the motor symptoms (Table 1). For some patients with PD, the neuropsychiatric complications are a greater source of morbidity than the motor dysfunction.[1,2] The neuropsychiatric disorders associated with dopaminergic therapies are important to recognize, because they are at least partially iatrogenic and can often be successfully managed by adjustment of the patient’s PD medications. We offer a detailed review in our article Management of Psychosis in Parkinson Disease.[3]

  • Dopamine agonists are more likely to provoke hallucinations than is carbidopa/levodopa. Psychosis with hallucinations and delusions has been reported in as many as 20% of nondemented patients who receive medications for PD (Table 2).[4,5]
  • The management of psychosis in PD with dementia is challenging (Table 3). In these patients, an attempt should be made to taper the use of combination therapy with dopamine agonists, anticholinergics, amantadine, MAO-B inhibitors, and COMT inhibitors.[6]

  • References

    1. Weiss HD, Marsh L. Impulse control disorders and compulsive behaviors associated with dopaminergic therapies in Parkinson disease. Neurol Clin Pract. 2012;2:267-273.

    2. Weintraub D, Burn DJ. Parkinson’s disease: the quintessential neuropsychiatric disorder. Mov Disord. 2011;26:1022-1031.

    3. Weiss HD, Adler S. Management of psychosis in Parkinson Disease. Psychiatric Times. May 1, 2014. http://www.psychiatrictimes.com/special-reports/management-psychosis-parkinson-disease

    4. Morgante L, Colosimo C, Antonini A, et al; PRIAMO Study Group. Psychosis associated to Parkinson’s disease in the early stages: relevance of cognitive decline and depression. J Neurol Neurosurg Psychiatry. 2012;83:76-82.

    5. Lee AH, Weintraub D. Psychosis in Parkinson’s disease without dementia: common and comorbid with other non-motor conditions. Mov Disord. 2012; 27:858-863.

    6. Thomsen TR, Panisset M, Suchowersky O, et al. Impact of standard of care for psychosis in Parkinson disease. J Neurol Neurosurg Psychiatry. 2008;79: 1413-1415.

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