The acronym SIMPLE, created by a research group in the US, is a general guideline to consider in order to prevent non-adherence:
Simplify drug regimen: for instance, reduce the frequency of a dosing regimen, or ensure that it suits a patient’s daily life.
Impart knowledge: educate patients about the disease and their DMTs; patient’s understanding of both positively correlates with adherence.
Modify patient beliefs: address patient’s expectations about adverse effects and effectiveness of DMTs.
Patient communication: enhancing physician/patient and physician/family communication as well as telephone or email reminders, can improve adherence.
Leave the bias: there is a belief that certain demographic characteristics are predictive of poor adherence, but the literature has shown that nonadherence can affect anyone, regardless of sex, age, education, or race.
Evaluate adherence: physicians infrequently discuss adherence, and tend to overestimate the adherence rates of their patients. It’s important to continually ask patients about how they’re adhering to their medication.