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New Insights About Accelerated Long-Term Forgetting in Epilepsy

New Insights About Accelerated Long-Term Forgetting in Epilepsy

  • Here’s evidence that accelerated long-term forgetting (ALF) may be an important memory disorder in subgroups of patients with epilepsy.
  • Accelerated Long-Term Forgetting: Overlooked in Epilepsy?

    ALF is memory loss that occurs after days or weeks in a patient with normal short-term memory

    Incidence rates and underlying causes of ALF in epilepsy are unknown

    Standard memory testing usually evaluates shorter term memory deficits, and may not detect ALF

    Research suggests that some patients with epilepsy may experience ALF, especially those with temporal lobe abnormalities

  • New insights on ALF in Focal Epilepsy[1]

    Conducted at the University of Sydney

    Included 44 patients with focal seizures

    Used two standardized, 15-item lists to test memory at 30 minutes and 7 days:

    Rey Auditory Verbal Learning Test (RAVLT): tests word recall

    Aggie Figures Test: tests recall of abstract line drawings

    ALF: normal short-term results, impaired 7-day results

    Compared results to a control group of 60 patients without neurological or psychological history

  • ALF Increased in Focal Epilepsy

    Nearly twice as many patients with focal seizures showed ALF vs controls (23% vs 12%)

    33% of patients with ALF had temporal lobe epilepsy

    Hippocampal lesions were the main predicting factor

       -ALF found in 41% of patients with hippocampal lesions vs only 11% without (p<.05)

  • Test Type Influences Detection of ALF

    Rates of ALF differed based on test type:

      -RAVLT: 18% of patients with focal epilepsy had ALF

      -Aggie Figure Test: 7% of patients with focal epilepsy had ALF

  • Standard Testing May Miss ALF in Focal Epilepsy

    Patients with focal seizures may show memory deficits at longer delays than standard evaluation can pick up

    Adding long term recall questions to standard memory assessments may detect ALF

    ALF may be most common in temporal lobe epilepsy with hippocampal lesions

  • Take Home Points

    .Small, single center study adds to evidence that ALF may be an important memory disorder in epilepsy

    .ALF prevalence may be higher in patients with temporal lobe epilepsy with hippocampal lesions

    .Standard testing may miss ALF

    .Incidence of ALF may vary based on type of test; testing word recall after one week may be particularly helpful in detecting ALF in focal epilepsy

  • 1. Miller LA, Mothakunnel A, Flanagan E, et al. Accelerated Long Term Forgetting in patients with focal seizures: Incidence rate and contributing factors. Epilepsy Behav. 2017;72:108-113. 

Comments

Have a problem with short term memory loss. I developed a choroidal ocular melanoma in my L. Eye back in the Spring of 2004. The presenting symptom complex was a large visual field loss.
Dr. David Meyer In Memphis, TN showed me what i had, and treated metric with plaque brachy therapy.with I-125 Each treatment lasted only7months verified by repeated beta-U/S scans.
I Have the parer work that describes the treatments. After the second treatment showed progression of the lesion, I lost the eye on 1 DEC 2006.
I will bring all my records with me when I come up next Tuesday.

Join M. Stefanov

John @

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