The acronym SIMPLE, created by a research group in the US
, is a general guideline to consider in order to prevent non-adherence:S
implify drug regimen: for instance, reduce the frequency of a dosing regimen, or ensure that it suits a patient’s daily life.I
mpart knowledge: educate patients about the disease and their DMTs; patient’s understanding of both positively correlates with adherence.M
odify patient beliefs: address patient’s expectations about adverse effects and effectiveness of DMTs.P
atient communication: enhancing physician/patient and physician/family communication as well as telephone or email reminders, can improve adherence.L
eave the bias: there is a belief that certain demographic characteristics are predictive of poor adherence, but the literature has shown that nonadherence can affect anyone, regardless of sex, age, education, or race.E
valuate adherence: physicians infrequently discuss adherence, and tend to overestimate the adherence rates of their patients. It’s important to continually ask patients about how they’re adhering to their medication.